CPC C07K 16/24 (2013.01) [A61P 11/00 (2018.01); A61P 35/04 (2018.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01)] | 20 Claims |
1. A pharmaceutical composition, comprising an antibody or an antibody fragment thereof as an active ingredient, the antibody or the antibody fragment thereof having a neutralizing antibody affinity for a heterodimer of S100A8 and S100A9, and wherein said antibody or said antibody fragment thereof comprises a combination of:
a heavy chain variable region (VH CDR) comprising the amino acid sequence set forth in SEQ ID NO: 7, 8, and 9; and
(ii) a light chain variable region (VL CDR) comprising the amino acid sequence set forth in SEQ ID NO: 22, 23, and 24.
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