US 11,858,976 B2
Nucleic acid constructs encoding chimeric NK receptor, cells containing, and therapeutic use thereof
Tong Zhang, Beijing (CN); and Charles L Sentman, West Lebanon, NH (US)
Assigned to THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed by THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed on Jun. 15, 2022, as Appl. No. 17/841,117.
Application 17/841,117 is a division of application No. 17/748,683, filed on May 19, 2022.
Application 17/748,683 is a division of application No. 16/458,740, filed on Jul. 1, 2019, granted, now 11,339,199, issued on May 24, 2022.
Application 16/458,740 is a division of application No. 14/600,799, filed on Jan. 20, 2015, granted, now 10,336,804, issued on Jul. 2, 2019.
Application 14/600,799 is a continuation of application No. 12/407,440, filed on Mar. 19, 2009, abandoned.
Application 12/407,440 is a continuation in part of application No. 11/575,878, granted, now 7,994,298, issued on Aug. 9, 2011, previously published as PCT/US2005/031100, filed on Aug. 31, 2005.
Claims priority of provisional application 60/681,782, filed on May 17, 2005.
Claims priority of provisional application 60/612,836, filed on Sep. 24, 2004.
Prior Publication US 2022/0402996 A1, Dec. 22, 2022
Int. Cl. C07K 14/705 (2006.01); A61K 38/10 (2006.01); C07K 14/715 (2006.01); A61K 35/17 (2015.01); A61K 45/06 (2006.01)
CPC C07K 14/705 (2013.01) [A61K 35/17 (2013.01); A61K 38/10 (2013.01); A61K 45/06 (2013.01); C07K 14/715 (2013.01)] 22 Claims
 
1. A nucleic acid construct which provides for the expression of a chimeric receptor which comprises:
a first nucleic acid sequence encoding a promoter operably linked to a second nucleic acid sequence encoding a chimeric receptor comprising a C-type lectin-like natural killer cell receptor, fused to a nucleic acid encoding an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif of SEQ ID NO: 1,
wherein the C-type lectin-like NK cell type II receptor is Dectin-1, Mast cell function-associated antigen, HNKR-P1A, LLT1, CD69, CD69 homolog, CD72, CD94, KLRF1, CLEC-1, CLEC-2, NKG2D, NKG2C, NKG2A, or NKG2E.