	US 11,858,974 B2
	Macrocyclic modulators of disease associated protein misfolding and aggregation
Georgios Skretas, Athens (GR)
Assigned to RESQ BIOTECH, Patra (GR)
Appl. No. 16/613,879
Filed by RESQ BIOTECH, Patra (GR)
PCT Filed May 22, 2018, PCT No. PCT/IB2018/000622 § 371(c)(1), (2) Date Nov. 15, 2019, PCT Pub. No. WO2018/215831, PCT Pub. Date Nov. 29, 2018.
Claims priority of application No. PCT/EP2017/025141 (WO), filed on May 22, 2017; and application No. PCT/EP2017/025298 (WO), filed on Oct. 5, 2017.
Prior Publication US 2020/0140506 A1, May 7, 2020
Int. Cl. C07K 14/47 (2006.01); G01N 33/68 (2006.01); C12N 15/10 (2006.01); A61K 38/00 (2006.01)

CPC C07K 14/4711 (2013.01) [C12N 15/1075 (2013.01); G01N 33/6896 (2013.01); A61K 38/00 (2013.01); G01N 2500/10 (2013.01); G01N 2800/2821 (2013.01)]

19 Claims

1. An engineered cyclic pentapeptide having an amino acid sequence NuX₁X₂X₃X₄, wherein: Nu is T; X₁is A, L, V, F, W, Y, C, S, T, D, R, P or G; X₂is S; X₃is A, L, V, F, W, Y, M, S, T, R, H or G; and X₄is W.