CPC C07K 14/47 (2013.01) [A61P 35/00 (2018.01); C07K 16/3007 (2013.01); C12N 15/815 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C12R 2001/84 (2021.05)] | 21 Claims |
1. A pharmaceutical composition comprising a molecule comprising:
a) a recombinant antibody targeting a tumor antigen, wherein the recombinant antibody comprises anti-CEA scFv MFE23 of SEQ ID No: 2; and
b) a granulysin polypeptide comprising SEQ ID NO:1,
wherein said recombinant antibody and said granulysin polypeptide are part of a single polypeptide chain; and
wherein the recombinant antibody is located at an N-terminal end of the single polypeptide chain and is physically bound by a peptide connector to the granulysin polypeptide.
|