CPC C07J 17/005 (2013.01) [A61K 9/1277 (2013.01); A61K 47/28 (2013.01); A61P 35/00 (2018.01); A61K 45/06 (2013.01); C07B 63/04 (2013.01)] | 28 Claims |
1. A blank liposome having a membrane, wherein the membrane comprises a lipid and a ginsenoside of Formula I:
wherein,
“*” represents a chiral carbon;
R1 is H, R10, R11 or hydroxy (OH);
R10 is selected from the group consisting of: —O-Glc, —O-Rha, —O-Lyx, —O-Xyl, —O-Ara(p), —O-Ara(f), —O-Glc(2→1)Glc, —O-Glc(6→1)Glc, —O-Glc(2→1)Rha, —O-Glc(2→1)Xyl, —O-Glc(6→1)Xyl, —O-Glc(6→1)Rha, —O-Glc(2→1)Ara(p), —O-Glc(6→1)Ara(p), —O-Glc(2→1)Ara(f), —O-Glc(6→1)Ara(f), —O-Glc(2→1)Glc(2→1)Glc, —O-Glc(2→1)Glc(2→1)Xyl, —O-Glc(6→1)Glc(6→1)Xyl, —O-Glc(2→1)Glc(4→1)Xyl, —O-Glc(2→1)Lyx, —O-Glc(6→1)Lyx, —O-Glc(2→1)Glc(2→1)Rha, —O-Glc(2→1)Glc(2→1)Lyx, —O-Glc(2→1)Glc(2→1)Ara(f), —O-Glc(2→1)Glc(2→1)Ara(p), —O-Glc(2→1)Glc(6→1)Glc, —O-Glc(2→1)Glc(6→1)Rha, —O-Glc(2→1)Glc(6→1)Xyl, —O-Glc(2→1)Glc(6→1)Lyx, —O-Glc(2→1)Glc(6→1)Ara(f), —O-Glc(2→1)Glc(6→1)Ara(p), —O-Glc(6→1)Glc(2→1)Glc, —O-Glc(6→1)Glc(2→1)Rha, —O-Glc(6→1)Glc(2→1)Xyl, —O-Glc(6→1)Glc(2→1)Lyx, —O-Glc(6→1)Glc(2→1)Ara(f), —O-Glc(6→1)Glc(2→1)Ara(p), —O-Glc(6→1)Glc(6→1)Glc, —O-Glc(6→1)Glc(6→1)Rha, —O-Glc(6→1)Glc(6→1)Lyx, —O-Glc(6→1)Glc(6→1)Ara(f) and —O-Glc(6→1)Glc(6→1)Ara(p); wherein Glc is glucopyranosyl, Xyl is xylopyranosyl, Rha is Rhamnopyranosyl, Ara(p) is arabinopyranosyl, Ara(f) is arabinofuranosyl, Lyx is Lyxosyl; number indicates carbon position, arrow (4) indicates the connection relationship, and the same hereinafter;
R11 is a group formed by replacing one or more OH groups in R10 with R10, and each of the one or more than one R10 groups is independently the same as or different from each other.
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