US 11,858,918 B2
GLP-1R modulating compounds
Megan K. Armstrong, San Francisco, CA (US); James S. Cassidy, San Francisco, CA (US); Elbert Chin, San Mateo, CA (US); Chienhung Chou, Dublin, CA (US); Jeromy J. Cottell, Redwood City, CA (US); Chao-I Hung, San Mateo, CA (US); Kavoos Kolahdouzan, San Francisco, CA (US); David W. Lin, Berkeley, CA (US); Michael L. Mitchell, Castro Valley, CA (US); Ezra Roberts, San Francisco, CA (US); Scott D. Schroeder, Union City, CA (US); Nathan D. Shapiro, Belmont, CA (US); James G. Taylor, Burlingame, CA (US); Rhiannon Thomas-Tran, San Jose, CA (US); Nathan E. Wright, San Diego, CA (US); and Zheng-Yu Yang, Palo Alto, CA (US)
Assigned to GILEAD SCIENCES, INC., Foster City, CA (US)
Filed by Gilead Sciences, Inc., Foster City, CA (US)
Filed on Apr. 19, 2022, as Appl. No. 17/724,212.
Claims priority of provisional application 63/286,475, filed on Dec. 6, 2021.
Claims priority of provisional application 63/177,778, filed on Apr. 21, 2021.
Prior Publication US 2023/0102927 A1, Mar. 30, 2023
Int. Cl. C07D 405/14 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/675 (2006.01); C07D 401/08 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 491/048 (2006.01); C07D 493/08 (2006.01); C07D 493/10 (2006.01); C07F 9/6558 (2006.01)
CPC C07D 405/14 (2013.01) [A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/675 (2013.01); C07D 401/08 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 491/048 (2013.01); C07D 493/08 (2013.01); C07D 493/10 (2013.01); C07F 9/65586 (2013.01)] 18 Claims
 
1. A compound of Formula (II):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
R1 is a phenyl or 6 membered heteroaryl optionally substituted with 1, 2, or 3 R4;
X1 is —C(H)═ or —C(R8)═;
X4 is —C(H)═, —C(R8)═, or N;
each R4 is independently halogen or —CN;
each RB is independently C1-9 alkyl, C1-8 haloalkyl, or halogen;
each R8 is independently halogen; and
n is 0, 1, 2, or 3.