US 11,858,910 B2
Pyridinylmethylenepiperidine derivatives and uses thereof
Chuanfei Jin, Dongguan (CN); Wenhe Zhong, Dongguan (CN); and Yaping Xue, Dongguan (CN)
Assigned to SUNSHINE LAKE PHARMA CO., LTD., Guangdong (CN)
Appl. No. 17/263,177
Filed by SUNSHINE LAKE PHARMA CO., LTD., Guangdong (CN)
PCT Filed Aug. 22, 2019, PCT No. PCT/CN2019/101985
§ 371(c)(1), (2) Date Jan. 26, 2021,
PCT Pub. No. WO2020/038435, PCT Pub. Date Feb. 27, 2020.
Claims priority of application No. 201810969837.5 (CN), filed on Aug. 24, 2018.
Prior Publication US 2021/0188803 A1, Jun. 24, 2021
Int. Cl. C07D 401/08 (2006.01); C07D 401/14 (2006.01)
CPC C07D 401/08 (2013.01) [C07D 401/14 (2013.01)] 19 Claims
 
1. A compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof,

OG Complex Work Unit Chemistry
wherein
L is —C(═O)—, —C(═S)— or —S(═O)2—;
R1 is C1-C6 alkyl, C3-C8 cycloalkyl, 3-8 membered heterocyclyl, C6-C10 aryl or 5-10 membered heteroaryl, wherein R1 is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from R1a, R1b, R1c, R1d and R1e;
each R1a, R1b, R1c, R1d and R1e is independently H, F, Cl, Br, I, —CN, —NO2, —NH2, —OH, —SH, —COOH, —C(═O)NH2, —C(═O)NHCH3, —C(═O)N(CH3)2, —C(═O)—(C1-C6 alkyl), —C(═O)—(C1-C6 alkoxy), C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1 —C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkylamino, hydroxy-substituted C1-C6 alkyl, C3-C8 cycloalkyl, 3-8 membered heterocyclyl, C6-C10 aryl or 5-10 membered heteroaryl;
R2 is H, F, Cl, Br, I, —CN, —NO2, —NH2, —OH, —COOH, —C(═O)NH2, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy or hydroxy-substituted C1-C6 alkyl;
each of R3, R4 and R5 is independently H, F, Cl, Br, I, —CN, —NO2, —NH2, —OH, —COOH, —C(═O)NH2, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy or hydroxy-substituted C1-C6 alkyl;
R6 is H, F, Cl, Br or I;
R7 is H, F, Cl, Br, I, —CN, —NO2, —NH2, —OH, —COOH, —C(═O)NH2, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy or hydroxy-substituted C1-C6 alkyl; and
R8 is H, F, Cl, Br, I, —CN, —NO2, —NH2, —OH, —SH, —COOH, —C(═O)NH2, —C(═O)NHCH3, —C(═O)N(CH3)2, —C(═O)—(C1-C6 alkyl), —C(═O)—(C1-C6 alkoxy), C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkylamino, hydroxy-substituted C1-C6 alkyl, C3-C8 cycloalkyl, 3-8 membered heterocyclyl, C6-C10 aryl or 5-10 membered heteroaryl.