US 11,858,909 B2
Deuterated etoricoxib, methods of manufacture, and use thereof
Bradford C. Sippy, Acton, MA (US)
Assigned to Tremeau Pharmaceuticals, Inc., Concord, MA (US)
Filed by Tremeau Pharmaceuticals, Inc., Concord, MA (US)
Filed on Aug. 27, 2021, as Appl. No. 17/459,838.
Application 17/459,838 is a continuation of application No. 17/240,446, filed on Apr. 26, 2021, granted, now 11,161,833.
Claims priority of provisional application 63/173,291, filed on Apr. 9, 2021.
Prior Publication US 2022/0332696 A1, Oct. 20, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/04 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01)
CPC C07D 401/04 (2013.01) [A61K 9/0053 (2013.01); A61K 45/06 (2013.01); C07B 2200/05 (2013.01)] 31 Claims
 
1. A method for treating acute pain in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the formula:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, hydrate, solvate, polymorph, co-crystal, metabolite, or prodrug thereof, or a pharmaceutical composition thereof.