CPC C07D 263/56 (2013.01) [A61P 31/14 (2018.01); C07D 231/56 (2013.01); C07D 277/64 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)] | 20 Claims |
1. A compound represented by formula (I-a):
wherein
R1 and R2 are independently selected from H, a —CH2— group, and an alkyl group;
R1 and R2 are unconnected or connected via a single bond;
W is CO or SO2;
R3 is an alkyl group, a fluoroalkyl group, a cycloalkyl group, an alkoxy group, an aryl group, a heteroaryl group, or a heterocyclic group, and R3 is optionally substituted by one or more groups selected from halogen, a hydroxyl group, an alkyl group, a fluoroalkyl group, a cycloalkyl group, an aryl group, a heterocyclic group, and an alkoxy group;
X1 is a CH group or N;
X2 is O, S, or N—R4, wherein R4 is selected from H, an alkyl group, an aryl group, and a heterocyclic group;
X3 is H, an alkyl group, a cycloalkyl group, an aryl group, a heteroaryl group, or a heterocyclic group, and X3 is optionally substituted by one or more groups selected from halogen, a hydroxyl group, an alkyl group, a fluoroalkyl group, a cycloalkyl group, and an alkoxy group;
Z1 is a CH group, C—R5, or N;
Z2 is a CH group, C—R6, or N;
Z3 is a CH group, C—R7, or N; and
Z4 is a CH group, C—R8, or N, wherein
R5—R8 are independently selected from H, halogen, a hydroxyl group, an alkyl group, a fluoroalkyl group, —CN, a cycloalkyl group, an alkoxy group, an aryl group, a heteroaryl group, and a heterocyclic group, and
each of R5-R8 is optionally substituted by one or more groups selected from halogen, a hydroxyl group, an alkyl group, a fluoroalkyl group, a cycloalkyl group, a heterocyclic group, a cycloalkyl group, an aryl group, and an alkoxy group.
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