US 11,858,904 B2
Process for preparing large size isoxazoline particles
Luke Ryan Schenck, Yardley, PA (US); Athanas Koynov, Metuchen, NJ (US); George X. Zhou, Princeton Junction, NJ (US); and Aaron Cote, West Windsor, NJ (US)
Assigned to Intervet Inc., New (JE)
Appl. No. 16/761,695
Filed by Intervet Inc., Madison, NJ (US)
PCT Filed Nov. 6, 2018, PCT No. PCT/EP2018/080230
§ 371(c)(1), (2) Date May 5, 2020,
PCT Pub. No. WO2019/091940, PCT Pub. Date May 16, 2019.
Claims priority of provisional application 62/608,904, filed on Dec. 21, 2017.
Claims priority of provisional application 62/582,381, filed on Nov. 7, 2017.
Prior Publication US 2020/0331867 A1, Oct. 22, 2020
Int. Cl. C07D 261/04 (2006.01); A01N 43/80 (2006.01)
CPC C07D 261/04 (2013.01) [A01N 43/80 (2013.01); C07B 2200/13 (2013.01)] 4 Claims
 
1. An isoxazoline compound particle composition comprising particles having a volume weighted particle size distribution (d50) as measured by a static light scattering instrument of between 50 and 150 μm and with a thickness of greater than 10 μm, as measured by scanning electron microscopy (SEM) wherein, the volume weighted particle size distribution (d50) as measured by a static light scattering instrument of the particles does not decrease by more than 40% when the mechanical resiliency as measured by a pressure titration is increased from 1 to 3 bar dispersion pressure, wherein the isoxazoline compound is fluralaner.