CPC C07C 251/86 (2013.01) [A01N 37/28 (2013.01); A61K 31/195 (2013.01); A61P 31/10 (2018.01); C07D 213/86 (2013.01); C07D 215/54 (2013.01); C07D 239/30 (2013.01); C07D 307/68 (2013.01); C07D 309/08 (2013.01); C07D 333/38 (2013.01); A61K 45/06 (2013.01)] | 20 Claims |
1. A method of inhibiting the growth of a fungus comprising contacting the fungus with an effective amount of the compound having the structure:
wherein
R1 is —H, alkyl, alkenyl, or alkynyl;
R2 is —H, alkyl, alkenyl, or alkynyl;
R3, R4, R5, and R6 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, or
R3 and R4 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, and R5 and R6 combine to form a fused aryl or fused heteroaryl, which are each unsubstituted or substituted, or
R3 and R6 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, and R4 and R5 combine to form a fused aryl or fused heteroaryl, which are each unsubstituted or substitute, or
R5 and R6 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, and R3 and R4 combine to form a fused aryl or fused heteroaryl, which are each unsubstituted or substituted; and
A is an aryl or heteroaryl, which are each unsubstituted or substituted,
wherein when R3, R4, and R6 are each —H and R5 is —OH or —OCH3, or R3, R5, and R6 are each —H and R4 is —Br, then A is other than ortho-tolyl or meta-bromophenyl,
or a pharmaceutically acceptable salt or ester thereof, so as to thereby inhibit the growth of the fungus.
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