US 11,857,969 B2
Digital microfluidics systems and methods with integrated plasma collection device
Mais J. Jebrail, Toronto (CA); Jorge Abraham Soto Moreno, San Francisco, CA (US); and Victor Lee, Richmond Hill (CA)
Assigned to mirOculus Inc., San Francisco, CA (US)
Filed by mirOculus Inc., San Francisco, CA (US)
Filed on Aug. 15, 2022, as Appl. No. 17/888,461.
Application 17/888,461 is a continuation of application No. 16/614,396, granted, now 11,413,617, previously published as PCT/US2018/043293, filed on Jul. 23, 2018.
Claims priority of provisional application 62/536,419, filed on Jul. 24, 2017.
Prior Publication US 2023/0049633 A1, Feb. 16, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. B01L 3/00 (2006.01)
CPC B01L 3/502792 (2013.01) [B01L 2200/0673 (2013.01); B01L 2300/166 (2013.01); B01L 2400/0427 (2013.01)] 16 Claims
OG exemplary drawing
 
1. An air-matrix microfluidic apparatus configured to process whole blood and manipulate plasma extracted from the whole blood, the apparatus comprising:
a first layer having a first hydrophobic surface;
a second layer having a second hydrophobic surface, the second layer having a sample outlet;
an air gap formed between the first and second layers;
a sample inlet positioned over the sample outlet, the sample inlet configured to receive a sample of whole blood;
a plasma separation membrane positioned between the sample inlet and the sample outlet, the plasma separation membrane configured to extract plasma into the sample outlet from the whole blood in the sample inlet; and
a controller programmed to drive an actuator to draw the plasma through the plasma separation membrane when the plasma extracted from the whole blood contacts the first layer.