US 11,857,813 B2
High intensity focused ultrasound systems for treating tissue
Yak-Nam Wang, Seattle, WA (US); Michael R. Bailey, Seattle, WA (US); Tatiana D. Khokhlova, Seattle, WA (US); Wayne Kreider, Seattle, WA (US); Adam D. Maxwell, Seattle, WA (US); George R. Schade, Seattle, WA (US); and Vera A. Khokhlova, Seattle, WA (US)
Assigned to University of Washington, Seattle, WA (US)
Filed by University of Washington, Seattle, WA (US)
Filed on Jul. 13, 2020, as Appl. No. 16/927,860.
Application 16/927,860 is a continuation of application No. 15/126,131, abandoned, previously published as PCT/US2015/023306, filed on Mar. 30, 2015.
Claims priority of provisional application 62/072,947, filed on Oct. 30, 2014.
Claims priority of provisional application 61/973,032, filed on Mar. 31, 2014.
Prior Publication US 2021/0038924 A1, Feb. 11, 2021
Int. Cl. A61N 7/00 (2006.01); A61N 7/02 (2006.01)
CPC A61N 7/02 (2013.01) [A61N 2007/0004 (2013.01); A61N 2007/0091 (2013.01)] 18 Claims
OG exemplary drawing
 
8. A method, comprising:
lysing cells in a target site and substantially preserving an extracellular matrix at the target site by transmitting, by an ultrasound source, pulses of high intensity focused ultrasound having a pulse length in a range of about 1 millisecond (ms) to about 10 ms and a duty cycle in a range of about 1% to about 5%, a focal region of the high intensity focused ultrasound overlapping the target site; and
simultaneously with transmitting the pulses of the high intensity focused ultrasound, perfusing, with a decellularization detergent, vessels of a tissue comprising the target site.