US 11,857,809 B2
Sonogenic stimulation of cells
Sreekanth H. Chalasani, La Jolla, CA (US); and Stuart Ibsen, La Jolla, CA (US)
Assigned to Salk Institute for Biological Studies, La Jolla, CA (US)
Filed by Salk Institute for Biological Studies, La Jolla, CA (US)
Filed on Sep. 23, 2020, as Appl. No. 17/029,143.
Application 17/029,143 is a continuation of application No. 14/843,108, filed on Sep. 2, 2015, granted, now 10,806,951.
Claims priority of provisional application 62/054,600, filed on Sep. 24, 2014.
Prior Publication US 2021/0213306 A1, Jul. 15, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 7/00 (2006.01); C12N 13/00 (2006.01); C07K 14/705 (2006.01); A61K 41/00 (2020.01); A61B 8/00 (2006.01); G01N 29/00 (2006.01); A61K 38/00 (2006.01)
CPC A61N 7/00 (2013.01) [A61K 41/0033 (2013.01); C07K 14/705 (2013.01); C12N 13/00 (2013.01); A61B 8/00 (2013.01); A61K 38/00 (2013.01); A61N 2007/0026 (2013.01); G01N 29/00 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method for altering the function or activity of neurons that innervate a targeted tissue portion of a mammalian subject, the method comprising:
applying ultrasound energy to the targeted tissue portion from an ultrasound source, wherein the neurons that innervate the targeted tissue portion are configured to express an exogenous, ultrasound-sensitive transmembrane protein, and
modulating the membrane potential of the neurons innervating the targeted tissue portion and expressing the exogenous, ultrasound-sensitive transmembrane protein to alter the function or activity of the neurons following application of the ultrasound energy.