US 11,857,701 B2
Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
Sarah Mayes, Austin, TX (US); and Christine E. Schmidt, Gainesville, FL (US)
Assigned to Board Of Regents, The University Of Texas System, Austin, TX (US)
Filed by Board Of Regents, The University Of Texas System, Austin, TX (US)
Filed on May 22, 2023, as Appl. No. 18/321,238.
Application 18/321,238 is a continuation of application No. 17/369,067, filed on Jul. 7, 2021, granted, now 11,744,926.
Application 17/369,067 is a continuation of application No. 16/400,259, filed on May 1, 2019, granted, now 11,058,802, issued on Jul. 13, 2021.
Application 16/400,259 is a continuation of application No. 15/596,685, filed on May 16, 2017, granted, now 10,314,950, issued on Jun. 11, 2019.
Application 15/596,685 is a continuation of application No. 14/803,258, filed on Jul. 20, 2015, granted, now 9,656,001, issued on May 23, 2017.
Application 14/803,258 is a continuation of application No. 13/269,344, filed on Oct. 7, 2011, granted, now 9,095,558, issued on Aug. 4, 2015.
Claims priority of provisional application 61/391,299, filed on Oct. 8, 2010.
Prior Publication US 2023/0355846 A1, Nov. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/04 (2006.01); A61K 31/195 (2006.01); A61L 31/14 (2006.01); A61K 31/192 (2006.01); A61L 31/16 (2006.01)
CPC A61L 31/041 (2013.01) [A61K 31/192 (2013.01); A61K 31/195 (2013.01); A61L 31/145 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); A61L 2300/414 (2013.01); A61L 2300/43 (2013.01); A61L 2300/62 (2013.01)] 20 Claims
 
1. An apparatus comprising:
a nerve wrap comprising first and second layers;
wherein the first layer includes a desiccated, translucent, amorphous hydrogel film, the hydrogel film comprising hyaluronic acid and alginate;
wherein the second layer includes collagen;
wherein (a) the first layer is fused to the second layer, (b) the first layer has at least 1% hyaluronic acid by dry weight; and (c) the first layer is anti-adhesive and non-attractive to cells and the second layer is adhesive to cells.