US 11,857,655 B2
Antimicrobial compositions comprising modified clay and nonionic triblock copolymers
Shanthi Appavoo, Bangalore (IN); Anindya Dasgupta, Bangalore (IN); Srikala Kumaran, Bangalore (IN); and Maya Treesa Saji, Bangalore (IN)
Assigned to Conopco. Inc., Englewood Cliffs, NJ (US)
Appl. No. 17/414,270
Filed by Conopco, Inc., Englewood Cliffs, NJ (US)
PCT Filed Nov. 25, 2019, PCT No. PCT/EP2019/082364
§ 371(c)(1), (2) Date Jun. 15, 2021,
PCT Pub. No. WO2020/126317, PCT Pub. Date Jun. 25, 2020.
Claims priority of application No. 18215295 (EP), filed on Dec. 21, 2018.
Prior Publication US 2022/0040066 A1, Feb. 10, 2022
Int. Cl. A61K 8/25 (2006.01); A61K 8/41 (2006.01); A61K 8/86 (2006.01); A61Q 11/00 (2006.01)
CPC A61K 8/25 (2013.01) [A61K 8/416 (2013.01); A61K 8/86 (2013.01); A61Q 11/00 (2013.01)] 14 Claims
 
1. An antimicrobial composition comprising:
a) a modified clay particle comprising an antimicrobial compound, the modified clay particle comprising:
(i) an asymmetric 1:1 or 2:1:1 clay particle comprising alternating tetrahedral and octahedral sheets terminating with a tetrahedral sheet at one external surface plane and an octahedral sheet at another external surface plane, and
(ii) at least one orally acceptable antimicrobial compound selected from a quaternary ammonium material selected from cetylpyridinium chloride (CPC), cetyltrimethylammonium chloride (CTAC), cetyltrimethylammonium bromide (CTAB), benzalkonium chloride (BKC), benzethonium chloride, cetrimide, quaternium, polyhexamethylene BH; antimicrobial alcohols; antimicrobial phenols; antimicrobial organic acids/salts; zinc pyrithione; ketoconazole; piroctone olamine; or combinations thereof, wherein the at least one antimicrobial compound is attached to a coordinating cation on an external surface plane of the clay particle; and
b) a nonionic triblock copolymer,
wherein the at least one antimicrobial compound is a quaternium ammonium material.