CPC A61K 8/25 (2013.01) [A61K 8/416 (2013.01); A61K 8/86 (2013.01); A61Q 11/00 (2013.01)] | 14 Claims |
1. An antimicrobial composition comprising:
a) a modified clay particle comprising an antimicrobial compound, the modified clay particle comprising:
(i) an asymmetric 1:1 or 2:1:1 clay particle comprising alternating tetrahedral and octahedral sheets terminating with a tetrahedral sheet at one external surface plane and an octahedral sheet at another external surface plane, and
(ii) at least one orally acceptable antimicrobial compound selected from a quaternary ammonium material selected from cetylpyridinium chloride (CPC), cetyltrimethylammonium chloride (CTAC), cetyltrimethylammonium bromide (CTAB), benzalkonium chloride (BKC), benzethonium chloride, cetrimide, quaternium, polyhexamethylene BH; antimicrobial alcohols; antimicrobial phenols; antimicrobial organic acids/salts; zinc pyrithione; ketoconazole; piroctone olamine; or combinations thereof, wherein the at least one antimicrobial compound is attached to a coordinating cation on an external surface plane of the clay particle; and
b) a nonionic triblock copolymer,
wherein the at least one antimicrobial compound is a quaternium ammonium material.
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