US 11,857,648 B2
Dimerization strategies and compounds for molecular imaging and/or radioimmunotherapy
Dexing Zeng, Portland, OR (US); Lingyi Sun, Pittsburgh, PA (US); and Yongkang Gai, Pittsburgh, PA (US)
Assigned to UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed by UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed on Nov. 2, 2018, as Appl. No. 16/179,817.
Application 16/179,817 is a continuation of application No. PCT/US2017/030662, filed on May 2, 2017.
Claims priority of provisional application 62/373,036, filed on Aug. 10, 2016.
Claims priority of provisional application 62/346,783, filed on Jun. 7, 2016.
Claims priority of provisional application 62/330,622, filed on May 2, 2016.
Prior Publication US 2019/0134240 A1, May 9, 2019
Int. Cl. A61K 51/08 (2006.01); C07K 16/30 (2006.01); C07K 7/06 (2006.01); C07K 7/64 (2006.01); G01N 33/50 (2006.01); G01N 33/60 (2006.01); A61K 51/10 (2006.01); A61K 47/68 (2017.01); C07D 255/02 (2006.01); C07D 257/02 (2006.01); A61K 9/51 (2006.01)
CPC A61K 51/082 (2013.01) [A61K 9/51 (2013.01); A61K 47/6893 (2017.08); A61K 51/1027 (2013.01); C07D 255/02 (2013.01); C07D 257/02 (2013.01); C07K 7/06 (2013.01); C07K 7/64 (2013.01); C07K 16/30 (2013.01); G01N 33/5008 (2013.01); G01N 33/60 (2013.01); C07K 2319/00 (2013.01)] 8 Claims
 
1. A compound for molecular imaging or therapy comprising:

OG Complex Work Unit Chemistry
wherein A comprises a first peptide and a chelator;
wherein B comprises a second peptide;
wherein the chelator comprises a chelating core selected from the group consisting of NOTA, NETA, CB-TE2A, CB-TE1A1P, TETA, Pycu2A, DiAmSar, DOTA, DTPA, PCTA, and DFO; and
wherein the first and the second peptide are independently selected from the group consisting of NGR, LLP2A, BBN(7-14), Tyr(3)-octreotate, DAPTA, RGD c(cNGRc), c(RGDyK), and RAD.