US 11,857,634 B2
Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids
Song Li, Wexford, PA (US); Jingjing Sun, Pittsburgh, PA (US); Yichao Chen, Pittsburgh, PA (US); Yixian Huang, Pittsburgh, PA (US); Yanhua Liu, Pittsburgh, PA (US); and Binfeng Lu, Pittsburgh, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Appl. No. 17/049,152
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
PCT Filed Apr. 20, 2019, PCT No. PCT/US2019/028418
§ 371(c)(1), (2) Date Oct. 20, 2020,
PCT Pub. No. WO2019/204799, PCT Pub. Date Oct. 24, 2019.
Claims priority of provisional application 62/660,515, filed on Apr. 20, 2018.
Prior Publication US 2021/0236645 A1, Aug. 5, 2021
Int. Cl. A61K 47/58 (2017.01); A61K 47/54 (2017.01); A61K 9/107 (2006.01); A61K 31/65 (2006.01); C12N 15/113 (2010.01)
CPC A61K 47/58 (2017.08) [A61K 9/1075 (2013.01); A61K 31/65 (2013.01); A61K 47/549 (2017.08); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/351 (2013.01)] 19 Claims
 
1. A formulation, comprising: a plurality of polymers comprising a hydrophobic polymer backbone formed via radical polymerization, a first plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer, wherein the first plurality of pendant groups is attached to the hydrophobic polymer backbone via a first linking group comprising at least a first aromatic group which is interactive via π-π stacking and the second plurality of pendant groups is attached to the hydrophobic polymer backbone via a second linking group comprising at least a second aromatic group which is interactive via π-π stacking,
a first therapeutic compound, and
a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and comprises a nucleic acid.