	US 11,857,571 B2
	Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using
Charles Sentman, Grantham, NH (US); and Michael Battles, Canaan, NH (US)
Assigned to THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed by THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed on Aug. 17, 2020, as Appl. No. 16/994,795.
Application 16/994,795 is a division of application No. 15/561,748, granted, now 10,744,157, previously published as PCT/US2016/024322, filed on Mar. 25, 2016.
Claims priority of provisional application 62/138,561, filed on Mar. 26, 2015.
Prior Publication US 2021/0030800 A1, Feb. 4, 2021
Int. Cl. A61K 35/17 (2015.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 51/10 (2006.01); A61K 39/00 (2006.01)

CPC A61K 35/17 (2013.01) [A61K 47/6835 (2017.08); A61K 51/1045 (2013.01); A61K 51/1096 (2013.01); A61P 35/00 (2018.01); C07K 16/2809 (2013.01); C07K 16/2833 (2013.01); C07K 16/2851 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01)]

20 Claims

1. A polynucleotide encoding an anti-major histocompatibility complex class I chain-related gene A (MICA) chimeric antigen receptor (CAR) comprising an anti-MICA antibody or antigen binding fragment thereof, wherein the anti-MICA antibody or antigen binding fragment thereof comprises a heavy chain variable region comprising the heavy chain complementarity determining regions 1, 2 and 3 (HCDR1, HCDR2 and HCDR3) respectively comprising the amino acid sequences of SEQ ID NO: 35; SEQ ID NO: 36; and SEQ ID NO: 22, and a light chain variable region comprising the light chain complementarity determining regions 1, 2 and 3 (LCDR1, LCDR2 and LCDR3) respectively comprising the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 28; and SEQ ID NO: 37.