US 11,857,352 B2
Positron imaging tomography imaging agent composition and method for bacterial infection
Peter Tonge, Setauket, NY (US); Zhuo Zhang, Coram, NY (US); Peter Smith-Jones, Port Jefferson, NY (US); Li Liu, Stony Brook, NY (US); and Hui Wang, Woodside, NY (US)
Assigned to THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, Albany, NY (US)
Appl. No. 16/330,679
Filed by The Research Foundation for the State University of New York, Albany, NY (US)
PCT Filed Sep. 6, 2017, PCT No. PCT/US2017/050248
§ 371(c)(1), (2) Date Mar. 5, 2019,
PCT Pub. No. WO2018/048882, PCT Pub. Date Mar. 15, 2018.
Claims priority of provisional application 62/518,674, filed on Jun. 13, 2017.
Claims priority of provisional application 62/383,779, filed on Sep. 6, 2016.
Prior Publication US 2019/0209103 A1, Jul. 11, 2019
Int. Cl. C07C 229/60 (2006.01); C07C 227/12 (2006.01); A61B 6/03 (2006.01); C07B 59/00 (2006.01); A61K 51/04 (2006.01); A61P 31/04 (2006.01)
CPC A61B 6/037 (2013.01) [A61K 51/0402 (2013.01); A61P 31/04 (2018.01); C07B 59/001 (2013.01); C07C 227/12 (2013.01); C07C 229/60 (2013.01)] 5 Claims
 
1. A composition comprising the compound having the structure:

OG Complex Work Unit Chemistry
or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier, wherein the ratio of the 4-amino-2-[18F]-flurobenzoic acid to the 4-amino-2-[19F]-flurobenzoic acid is in the range from 1:90 to 1:550.