US 11,857,343 B2
Microneedle fabrication and device implantation
Timothy L. Hanson, San Francisco, CA (US); and Philip N. Sabes, San Francisco, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 16/463,323
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Nov. 28, 2017, PCT No. PCT/US2017/063492
§ 371(c)(1), (2) Date May 22, 2019,
PCT Pub. No. WO2018/102307, PCT Pub. Date Jun. 7, 2018.
Claims priority of provisional application 62/428,352, filed on Nov. 30, 2016.
Prior Publication US 2020/0060615 A1, Feb. 27, 2020
Int. Cl. B21F 45/00 (2006.01); A61B 5/00 (2006.01); A61B 5/1459 (2006.01); A61B 5/1473 (2006.01); A61K 41/00 (2020.01); A61N 1/05 (2006.01); A61N 5/06 (2006.01); B23K 101/32 (2006.01); B23K 1/00 (2006.01)
CPC A61B 5/685 (2013.01) [A61B 5/1459 (2013.01); A61B 5/1473 (2013.01); A61B 5/6868 (2013.01); A61K 41/0028 (2013.01); A61N 1/0502 (2013.01); A61N 1/0529 (2013.01); A61N 1/0551 (2013.01); A61N 5/0601 (2013.01); B21F 45/008 (2013.01); A61B 2562/12 (2013.01); A61N 2005/0612 (2013.01); A61N 2005/0651 (2013.01); B23K 1/0008 (2013.01); B23K 2101/32 (2018.08)] 42 Claims
OG exemplary drawing
 
1. A method of making a microneedle comprising a reversible engagement feature, the method comprising:
winding a first length of wire and a second length of wire under tension to generate a primary helix;
brazing the primary helix with a braze material to produce a microneedle comprising the first and second lengths of wire;
fatiguing the first length of wire of the microneedle at its distal end to fracture the first length of wire thereby generating a reversible engagement feature along the second length of wire at the point of fracture.