US 11,857,244 B2
Methods, systems, and apparatuses for tissue ablation using pulse shape designs
Boris Rubinsky, El Cerrito, CA (US); Paul Mikus, Rancho Mission Viejo, CA (US); Liel Rubinsky, El Cerrito, CA (US); Michael Klaus Stehling, Rödermark (DE); and Enric Günther, Hattersheim (DE)
Assigned to Inter Science GmbH, Gisikon (CH); and RM2 Technology LLC, Miami, FL (US)
Filed by INTER SCIENCE GMBH, Gisikon (CH); and RM2 TECHNOLOGY LLC, Rancho Mission Viejo, CA (US)
Filed on Mar. 8, 2021, as Appl. No. 17/195,298.
Application 17/195,298 is a division of application No. 15/570,914, granted, now 10,939,949, previously published as PCT/US2015/030628, filed on May 13, 2015.
Claims priority of provisional application 62/155,623, filed on May 1, 2015.
Prior Publication US 2021/0186592 A1, Jun. 24, 2021
Int. Cl. A61B 18/12 (2006.01); A61N 1/32 (2006.01); A61B 18/14 (2006.01); A61N 1/20 (2006.01); A61B 18/00 (2006.01); A61B 5/145 (2006.01)
CPC A61B 18/1206 (2013.01) [A61B 18/1402 (2013.01); A61N 1/205 (2013.01); A61N 1/327 (2013.01); A61B 5/14539 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00827 (2013.01); A61B 2018/00994 (2013.01); A61B 2018/1266 (2013.01); A61B 2018/1472 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method for tissue ablation, the method comprising:
delivering a pulse of a current or a voltage to a treatment site, the pulse comprising a falling edge that comprises an exponential decay;
wherein a magnitude and a duration of the pulse is selected to induce electroporation at the treatment site, and
wherein the duration of the pulse is further selected to produce an amount of electrolytic products at the treatment site.