	US 11,856,927 B2
	Finding and treatment of inflammation after birth in chimeric animal
Hiromitsu Nakauchi, Tokyo (JP); Tomoyuki Yamaguchi, Tokyo (JP); Sanae Hamanaka, Tokyo (JP); Hideyuki Sato, Tokyo (JP); Hideki Masaki, Tokyo (JP); Naoaki Mizuno, Tokyo (JP); and Motoo Watanabe, Tokyo (JP)
Assigned to The University of Tokyo, Tokyo (JP)
Appl. No. 16/480,169
Filed by The University of Tokyo, Tokyo (JP)
PCT Filed Jan. 25, 2018, PCT No. PCT/JP2018/002178 § 371(c)(1), (2) Date Oct. 17, 2019, PCT Pub. No. WO2018/139502, PCT Pub. Date Aug. 2, 2018.
Claims priority of application No. 2017-011349 (JP), filed on Jan. 25, 2017.
Prior Publication US 2020/0137991 A1, May 7, 2020
Int. Cl. A01K 67/027 (2006.01); A61P 37/06 (2006.01); A61K 31/573 (2006.01); C12N 15/09 (2006.01)

CPC A01K 67/0271 (2013.01) [A61K 31/573 (2013.01); A61P 37/06 (2018.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/035 (2013.01); C12N 15/09 (2013.01)]

12 Claims

1. A method for obtaining an adult individual from a xenogeneic or allogeneic chimeric animal fetus individual, the method comprising:

providing a xenogeneic or allogeneic chimeric animal fetus individual that shows no substantial inflammation;

obtaining an adult individual from the fetus individual by growing the fetus individual; and

administering an effective amount of an anti-inflammatory agent or an immunosuppressive agent to the individual before the birth of the individual and/or after the birth, wherein the effective amount is sufficient to suppress inflammation after the birth of the individual.